Modeling the tumor growth profiles in xenograft experiments--letter.

Statement of translational relevance: The new statistical model we propose in this study provides a comprehensive analysis of the tumor growth profiles observed in tumor xenograft experiments, including tumor regression rate, regression period, nadir volume and tumor regrowth rate. Each of these features provided by this model could have clinical implications for treatment. For example, higher regression rate, longer regression time, and lower regrowth rate could predict longer intervals to, and/or less frequent, tumor recurrence. This statistical approach maximizes the biological information obtained from tumor xenografts which should facilitate the translation of preclinical xenograft studies to more rationale clinical trial designs. Published OnlineFirst on December 3, 2010 as 10.1158/1078-0432.CCR-10-1935